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Selasa, 26 Agustus 2014

Free Ebook The Language of Life: DNA and the Revolution in Personalized Medicine, by Francis S. Collins

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The Language of Life: DNA and the Revolution in Personalized Medicine, by Francis S. Collins

The Language of Life: DNA and the Revolution in Personalized Medicine, by Francis S. Collins


The Language of Life: DNA and the Revolution in Personalized Medicine, by Francis S. Collins


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The Language of Life: DNA and the Revolution in Personalized Medicine, by Francis S. Collins

Review

“His groundbreaking work has changed the very ways we consider our health and examine disease.” (President Barack Obama)“The future of customized medicine is in your DNA; don’t wait until you are sick to learn why.” (Dr. Mehmet Oz, author of You: The Owner's Manual)“With fluid prose and compelling narratives, Francis Collins makes modern medical science vivid and accessible. This book sets out hope without hype, and will enrich the mind and uplift the heart.” (Jerome Groopman, M.D., Recanati Professor, Harvard Medical School, Author of How Doctors Think)“Man’s knowledge of man is undergoing the greatest revolution since Leonardo, and Francis Collins is at the leading edge of it. I am a better doctor today because Dr. Collins was my genetics professor in medical school, and now, the world gets to benefit from his wisdom by reading The Language of Life.” (Dr. Sanjay Gupta, Neurosurgeon at Emory University and Chief Medical Correspondent for CNN)

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From the Back Cover

A scientific and medical revolution has crept up on us. Twenty-one million Americans are affected by 6,000 so-called rare and orphan diseases, many of which are primarily attributable to misspelled genes. And virtually all diseases have a significant hereditary component. Diabetes, heart disease, the common cancers, mental illness, asthma, arthritis, Alzheimer's disease, and more are having their secrets unlocked through DNA. Families that faced common problems, without hope, are now discovering a new world of understanding, treatment, and prevention. You owe it to yourself to learn about your DNA: how it works, what it reveals, and the benefits and limits of this new knowledge.

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Product details

Paperback: 368 pages

Publisher: Harper Perennial; 1 edition (January 18, 2011)

Language: English

ISBN-10: 0061733180

ISBN-13: 978-0061733185

Product Dimensions:

5.3 x 0.9 x 8 inches

Shipping Weight: 8 ounces (View shipping rates and policies)

Average Customer Review:

4.6 out of 5 stars

53 customer reviews

Amazon Best Sellers Rank:

#235,784 in Books (See Top 100 in Books)

Outstanding and accessible book that fleshes out the history of human genetics in the recent past, much of which was firsthand as Dr. Collins has a large role to play in this story. This is not a history though, but rather gleans from some big revelations and technological developments over the past three decades the overarching themes that we now know as personalized medicine (or even more recently, precision medicine). Delving into a wealth of data and with remarkable clarity, Collins demonstrates the absolute necessity for medicine to move into new paradigms that harness personalized medicine.In a fairly salient moment of the book, Collins sends his DNA to three genotyping companies (23andme, Decode, and Navigenics) and gets three different answers as to his chances of getting prostate cancer. He then sifts through the meaning of these predictions and clearly explains why the current state of affairs needs so much work. Future doctors, policy makers, or patients would do well to read and re-read this book.

This is an excellent read! Francis Collins does an outstanding job at presenting complex DNA material in a simplified way for any student or learner in any discipline or field of expertise. Although Collins is a world-class scientist, He does not use technical language, but rather presents a clear case for personalized medicine in common language. In essence, Collins demonstrates that the days are coming when individual DNA analysis to determine predispositions towards certain illnesses will be as common as a physical check-up. In other words, DNA screening will be used to help determine the likelihood of someone falling victim to future diseases and sicknesses.In layman terms, the days are coming when you will have the option to know if you are prone toward cancer, heart disease, diabetes, etc. Francis Collins suggests that future DNA analysis may be used for certain preventative measures. While some may not have an interest in knowing their potential future health condition (que sera sera), others will. I, personally, am of the latter mindset. I prefer to know what my potential future holds in terms of health. In this way, I can do my best to prevent certain diseases as a good steward of the body God has given me. I think my wife, children and friends deserve it.

The Language of Life was one of the best-written books I've read on personal genomics and the future of genetic medicine. It is written by Francis Collins, an obvious pioneer in the field, who now has an extremely influential position in American science. The book gives an overview of many of the important genomic advances through Collins' eyes, giving a personal touch on the science. It is very interesting how Collins describes how he has subjected himself to various personal genomic tests and he explains in simple language what they meant to him. In particular, Collins relates many examples of where genetic knowledge is powerful in terms of individual people's livelihood. For instance, he tells the story a woman finding out that her family was afflicted by long Qt interval, which causes sudden death and the way they tried to watch for this (eg home defibrillator) . He tells how genomics is redefining ancestry with a story about a prominent individual that thought he was black but didn't turn out to have much African DNA. There is one small sloppiness that I uncovered in the book: Collin's saying that John Nash won a Nobel for mathematics. (He actually won the prize in economics.)

Dr. Collins is exceptionally qualified to write a book of this nature and he has made the contents have real life texture with the examples he uses. He does a very good job of giving you a feel of the future direction and the pace of development that is going on in genetics as it relates to medicine. His discussion of the variability in the effectiveness of medicines is particularly captivating. He provides the tools you need to understand the material as a layman.

A very interesting subject. That Francis S. Collins is an expert on the subject.

There was a lot of interesting information in this book, although much of it was anecdotal. My main reason for giving it only 3 stars however, is that I often felt I was reading an advertisement or at least a cheerleading piece for the wonders of personalized medicine. Don't get me wrong, I think there is a lot of potential in this field and it is very exciting the new discoveries that are coming on line, but I felt we aren't quite as there as this book might make a reader think.For instance, the author downplays the fact that 2 of the 3 DNA tests he got gave conflicting results as to whether or not he was more or less likely to get a particular disease. He knows enough about the subject to find out which is correct. But how about the layman? Or the person who only orders one test? Since his premise is that people might be more inclined to change their behavior if they knew their medicial risks, couldn't this very well lead to exactly the wrong kind of change, or less severe but still an obvious lost opportunity, no changes or a false sense of security where some changes would have been beneficial?I also am not convinced that people will make long term behavior changes based on their DNA reading if they're not willing to make them based on family history or doctor's advice, especially as for most conditions the changes are generally still eat healthier, exercise more and don't smoke.However, if you've not read anything else on the topic, it's an easy and accessible introduction. I would also recommend the $1000 Genome if you are interested in this topic.

This book explains many ways our physical body is affected by that which we receive from our ancestors. I'm amazed at the wealth of knowledge this field of scientific investigation has produced. And even more amazed at the amount of information still to be uncovered to benefit humanity.We are blessed by the Creator God that gave us life.Rheumell Prangley

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Senin, 25 Agustus 2014

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Product details

File Size: 2406 KB

Print Length: 192 pages

Publisher: Nicholas Brealey (November 7, 2017)

Publication Date: November 7, 2017

Sold by: Hachette Book Group

Language: English

ASIN: B0769ZTK75

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Nice book, great stories. It would have been smart to include the CD. What was the publisher thinking??

meh...

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This is a great book. I heard about it in the Life of a Song podcast and decided to buy it. If you enjoy music it is a must have. The stories about each song are interesting and well written and the book covers a variety of musical genres. So glad I bought it.

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Sabtu, 23 Agustus 2014

Download Mind, Heart, and Soul: Intellectuals and the Path to Rome, by Robert P. George

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Mind, Heart, and Soul: Intellectuals and the Path to Rome, by Robert P. George


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Mind, Heart, and Soul: Intellectuals and the Path to Rome, by Robert P. George

About the Author

Robert P. George holds Princeton's celebrated McCormick Chair in Jurisprudence and is the Director of the James Madison Program in American Ideals and Institutions. He has served as chairman of the United States Commission on International Religious Freedom, and before that on the President’s Council on Bioethics and as a presidential appointee to the United States Commission on Civil Rights. He has also served as the U.S. member of UNESCO’s World Commission on the Ethics of Scientific Knowledge and Technology. His many books include In Defense of Natural Law; Making Men Moral; Embryo: A Defense of Human Life; What is Marriage? Man and Woman: A Defense. A graduate of Swarthmore College, he holds J.D. and M.T.S. degrees from Harvard University and the degrees of D.Phil., B.C.L., and D.C.L. from Oxford University. R. J. Snell directs the Center on the University and Intellectual Life at the Witherspoon Institute in Princeton, NJ. Prior to this appointment he was for many years Professor of Philosophy and Director of the Philosophy Program at Eastern University and the Templeton Honors College, where he founded and directed the Agora Institute for Civic Virtue and the Common Good. A convert to Catholicism, he grew up Baptist and received his early education at the schools of Prairie Bible Institute and Liberty University. His first encounter with Rome occurred while pursuing an M.A. in philosophy at Boston College, where he took several courses with Peter Kreeft. Later he earned a Ph.D. in philosophy at Marquette University. He is the author of several books as well as articles, chapters, and essays in a variety of scholarly and popular venues.

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Product details

Hardcover: 266 pages

Publisher: TAN Books (November 12, 2018)

Language: English

ISBN-10: 1505111218

ISBN-13: 978-1505111217

Product Dimensions:

5.8 x 0.8 x 8.8 inches

Shipping Weight: 15.5 ounces (View shipping rates and policies)

Average Customer Review:

5.0 out of 5 stars

1 customer review

Amazon Best Sellers Rank:

#270,960 in Books (See Top 100 in Books)

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Jumat, 22 Agustus 2014

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Product details

File Size: 354 KB

Print Length: 272 pages

Publisher: Henry Holt and Co. (BYR) (June 16, 2015)

Publication Date: June 16, 2015

Language: English

ASIN: B00X3KABCG

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Before reading "The Year The Gypsies Came" by Linzi Glass I read all the glowing reviews with a skeptic's eye. Now that I have just completed this book let me rush to join the chorus who sing its praises.This intimate family story envelops the reader not only in the personal, but also in the larger story of Apartheid in South Africa. The novel becomes increasingly engaging as it unfolds. Especially compelling is the relationship between the young narrator, Emily, and the elderly Zulu night watchman with his wondrous tales filled with poetic wisdom.The impressive narrative is tightly woven and moves inexorably forward. Every word, phrase and sentence is there for a reason. How refreshing and unusual it is to find a book that is neither too long, nor hopelessly marred by excessive details.Linzi Glass' remarkable achievement is that through her lyrical prose she presents simultaneously the astonishing beauty of her native South Africa along with its correspondent sadness.Some of my best friends are my books. I often go back to a select few and reread passages that I have found to be particularly memorable. Surely "The Year The Gypsies Came" will join my group of special friends.

Set in South Africa in the early 1960's the story is about a dysfunctional family who play host to a family of displaced wanders. Beautifully written, the tale enfolds a rich carpet of characters and events that have a far-reaching affect on all involved.I was captivated with this book.

The Iris family lives in Johannesburg, Africa. Where you can "fall asleep with the faint roar of a lion or the laugh of a hyena coming across the lake." Their story takes place in the Spring of 1966 and is described through the eyes of the youngest member, twelve-year-old Emily. Other members of the family include mother Lily, father Bob and older sister Sarah.Emily has short dark hair and is a tomboy. She thinks dolls are boring and hates the colour pink. Her only friend in school is Cynthia Wright but her most important relationship is the one she has with her sister. She and Sarah are always compassionate to one another even with something as simple as a game of checkers.Bob comes home to let them know he ran into some 'gypsies' on one of his walks and they accepted his offer to park their trailer at the end of their estate. The Gypsies are made up of Jock and Peg Mallory and their two sons Streak and Otis. They aren't real gypsies but have travelled the continent in their trailer since before the boys were born. Jock supports his family as a wild life photographer. The boys immediately take a liking to the Iris girls spending any time they can with them outside of the girls' school.Another important character is sweet Buza, the night watchman/gate keeper. He is an elderly Zulu man and story teller who walks with a cane and tells stories to Emily when she comes to visit him in the watch house. He is her confidant and surrogate parent. Through him Linzi Glass laces short African tales which offer their own little morals within a few pages. One of my favourite was the story of Ma-We and the honey guide. Others include the phython story, the wolf story, the story of Rolihlahla and the story of two sisters, Yaphansi and Intombi. I would love to read more about Buza and his history.As the weeks pass Emily becomes stricken by the stories Streak shares with her about his family. Her own family doesn't look so bad after all. A growing fear murmurs inside her whenever she's around Jock. It isn't until one fearful night she realizes her fear was misdirected. But by then it's too late and her and Sarah's lives are changed forever.The use of simile is overbearing at times and some of the content is a little more mature than I would like for young adult readers. At the end is a helpful glossary of Afrikaans / Zulu words and Expressions. The Year of the Gypsies Came is Linzi Glass' first novel and she has created a compelling story with interesting characters. I couldn't help but care about them and I could literally feel the tension the author creates for Emily and Sarah when their parents argue. It's painful. The love Emily feels for Sarah and Buza is palpable. I was touched by their relationships. This book is worth reading for its sentiment and hint of African culture. Reviewed by M. E. Wood

Another book that I wanted to read after my high school librarian booktalked it.Set in South Africa during Apartheid, Emily's family is falling apart. Mother and Father rarely speak, and when they do it is just to argue. Mother is upset that Father isn't keeping her in the lifestyle that she imagined for herself, and Father is tired of Mother's browbeating. The only time that her parents seem to stop arguing is when other people stay at their compound. This time it's the gyspies.Not gypsies like one would imagine, her Father assures Emily. This is a wandering family from Australia. Jock, the nature photographer, wife Peg (with her omnipresent snake Opalina around her neck), and sons Otis and Streak. It's plain to see that Otis is simply not right in the head, and Streak is a bit of a wild one himself. Emily immediately takes to Streak, and sister Sarah is so kind and gentle that Otis' ways do not seem to bother her.The family's night watchman, Buza, has a bad feeling about these visitors. Emily spends her evenings with Buza, listening to his Zulu stories. He is the only person who can make Emily feel whole as her family splinters apart.***************This is a beautifully written tragedy. Emily is young enough that her emotions are raw and on the surface and Linzi Glass writes her voice perfectly. In fact there are no weak characters in this story. Each is integral, and everyone grows in some way.I have a bit of an interest in South Africa as a friend of mine lived there for several years, and I have recently aquired a South African penpal. However, I think that this is a book that will appeal to most fans of the written word. It is not for younger YAs as themes of infidelity, sexual abuse, and death are present. It is, however, wonderfully written and a pleasure (despite the pain) to read.

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